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| 1) | 造血器悪性腫瘍の成因としての遺伝子異常・ウイルス感染症（とくにＥＢウイルス感染症） |
| 2) | 遺伝子異常・ウイルス感染症によりもたらされる細胞の異常増殖の機序 |
| 3) | 細胞分裂の仕組み |
| 4) | 造血器悪性腫瘍の遺伝子診断・免疫学的診断 |
| 5) | ＥＢウイルスにより起こるＮＫ細胞リンパ腫の遺伝子治療 |
| 6) | 新しい造血幹細胞移植療法の開発 |
| 7) | 移植片対宿主病の予防と対策 |
| 8) | 造血障害の成因と病態 |
| 9) | 血液疾患に伴うリンパ球異常 |
| 10) | 抗癌剤の作用機序 |
| 11) | 造血器腫瘍細胞の薬剤耐性機序 |
| 12) | 血小板接着分子の活性化機構 |
| 13) | インテグリンのシグナル伝達機構 |
| 14) | 日和見感染の診断と治療 |
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血液内科医師の博士論文
Fukuda
J, Kaneko T, Egashira M, Oshimi K. Direct measurement of CD34+ blood stem
cell absolute counts by flow cytometry. Stem Cells 16: 294-300, 1998
Egashira
M, Kawamata N, Sugimoto K, Kaneko T, Oshimi K . P-glycoprotein expression
on normal and abnormally expanded natural killer cells and inhibition of P-glycoprotein
function by cyclosporin A and its analogue, PSC833. Blood 93: 599-606,
1999
Sato E, Kawamata N, Kato A, Oshimi K . A novel mutation
that leads to a congenital factor XI deficiency in a Japanese family. Am
J Hematol 63: 165-169, 2000
Sakajiri S, Kawamata N, Egashira M, Mori K,
Oshimi K Molecular analysis of tumor suppressor genes, Rb, p53, p16INK4A,
p15INK4B and p14ARF in natural killer cell neoplasms. Jpn J Cancer Res
92: 1048-56, 2001
Sigimoto K, Kawamata N, Sakajiri S, Oshimi K.
Molecular analysis of oncogenes, ras family genes ( N-ras, K-ras,
H-ras ), myc family genes ( c-myc, N-myc ) and mdm2
in natural killer cell neoplasms. Jpn J Cancer Res 93: 1270-1277,
2002
Isobe Y, Sugimoto K, Yang L, Tamayose K, Egashira M, Kaneko T, Takada
K, Oshimi K. Epstein-Barr virus infection of human natural-killer cell
lines and peripheral blood natural killer cells. Cancer Res 64: 2167-2174,
2004.
Ando M, Sugimoto K, Kitoh T, Sasaki M, Mukai K, Ando J, Egashira
M, Schuster SM, Oshimi K.
Selective apoptpsis of natural killer-cell tumours
by l-asparaginase. Br J Haematol 130:860-868,2005
M Sasaki,K Sugimoto,K
Tamayose,M Ando,Y Tanaka and K Oshimi
Spindle checkpoint protein Bub1 corrects
mitotic aberrancy induced by human T-cell leukemia virus type I Tax
Oncogene
25:3621-3627,2006
Ando J,Sugimoto K,tamayose K,Sasaki M,Ando M,Oshima K.
Changes in cell morphology and cytoskeletal organization are induced by human mitotic checkpoint gene, Bub1.
Biochem Biophys Res Commun,365(4):691-7,2007
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